Hereditary Cancers: Understanding Genetic Testing for Cancer Risk

About 5 to 10% of cancers are hereditary due to inherited genetic mutations. A Hereditary Cancer Panel is a genetic test that examines specific genes associated with an increased risk of cancer. This test helps individuals understand their inherited risk and take proactive steps for early detection and prevention.

What Is Hereditary Cancer Panel?  Hereditary Cancer Panel analyzes around 48 genes that are associated with pre-disposition to cancers of breast, ovary, uterus, prostate, and gastrointestinal

Who Should Consider This Test? This genetic test is recommended for individuals with:

  • A person with a strong family history of certain type of cancer
  • Multiple relatives affected by the same or related types of cancer
  • known genetic mutation in the family
  • A person who is already diagnosed with cancer

Benefits of Genetic Testing

  • Early Detection: Identifying a genetic predisposition enables timely screening and intervention. It also helps to confirm clinical predicts disease progression, and facilitates early detection of symptoms.
  • Personalize treatment :Assist with the development of a personalized treatment and management strategy 
  • Family Guidance: Knowing genetic risks can help family members make informed health decisions.

Interpreting the Results A positive result indicates a mutation that increases cancer risk, while a negative result means no detectable mutation was found. A variant of uncertain significance (implies that the mutation is not completely understood at this time) may require further evaluation. Consultation with a genetic counselor is essential to understand the implications of the test results.

Next Steps After Testing Based on the results, healthcare providers may recommend:

  • More frequent cancer screenings
  • Preventive treatments, such as medication or surgery
  • Lifestyle modifications to reduce risk
  • Family member testing for better risk assessment